Seroquel & Effexor CaliBazzMan I suffer from sleep disorder and anxiety once in a while, i was taking xanax.5mg every night to be able to sleep but now I want to get completely off it. Hi Psychocandy, I don't know about your particular AD, but from what I've read about Seroquel, it should not be taken with an AD because of bad interactions. Can Seroquel and Effexor be taken together? Find expert answers to this and other Seroquel questions at Caring.com. Find expert answers to this and other Seroquel questions at Caring.com. seroquel and effexor together Anyone take Zyprexa and Seroquel together? Hi there, I am on seroquel and effexor, I am also on epilim for my bipolar, for me the combination works really well although my seroquel dose is 50 mg, i think there are two strengths of seroquel. I decided to put the boat in the water to do some fishing and I couldn't even concentrate! Has anyone taken Seroquel and Effexor at the same time, and if so what were the feelings youo experienced your first time. They can be taken together at lower doses than you would take if each were on its own. It'll just zonk you out, you'll be walking aroud like a zombie. SEROQUEL XR for Major Depressive Disorder SEROQUEL XR may help improve your unresolved symptoms of depression when added to an antidepressant. SEROQUEL XR is FDA approved to treat major depressive disorder as add-on therapy to an antidepressant medication. Yes, in fact, Seroquel taken in the evening can help with the insomnia caused by Effexor.I have seen them prescribed together. My mom is currently taking 300 mg of Seroquel at night and 150 mg of Effexor during the day. She has been in bed alot lately due to a variety of other health problems. However, I am trying to determine if the seroquel and effexor could be causing this side effect. She is very weak, wobbly and unsteady while walking. Compare Effexor vs. Seroquel, which is better for uses like: Depression, Anxiety and Panic Attacks. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Effexor 3.2/5 over Seroquel 3.1/5 in overall satisfaction.